威尼斯615vip游戏(中国)官方网站IOS/安卓通用版/手机APP

教授

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教授、博士生导师、课题组长

邮箱：cxzhuo@xmu.edu.cn

地址：威尼斯615vip游戏卢嘉锡楼616
　　　福建省厦门市思明区思明南路422号，361005

ORCID: https://orcid.org/0000-0002-2805-9632

课题组网站：https://zhuolab.xmu.edu.cn/

个人简历：

2019.04-至今威尼斯615vip游戏，教授、博士生导师
2014.12-2019.03 德国马普煤炭所，洪堡学者，博士后（导师：Prof. Alois Fürstner）
2014.07-2014.10 中国科学院上海有机化学研究所，研究助理（导师：游书力研究员）
2009.09-2014.07中国科学院上海有机化学研究所，博士（导师：游书力研究员）
2005.09-2009.07 湖南大学化学系，学士

荣誉与获奖情况：

2022 Science of Synthesis Early Career Advisory Board
2022 Thieme Chemistry Journals Award
2019 国家高层次青年人才
2019 福建省闽江学者奖励计划特聘教授
2017 国家自然科学二等奖（第五完成人）
2016 上海市自然科学一等奖（第五完成人）
2015 中国科学院优秀博士论文
2015 德国洪堡奖学金
2014 中国科学院院长奖学金特别奖
2014 中国科学院优秀毕业生
2013 “Lecture Award” of the Roche and RSC International Chemistry Symposium
2013 “Student Travel Award” of the Roche and RSC International Chemistry Symposium
2013博士生国家奖学金
2013 M. Braun奖学金
2013 汪猷奖学金
2008 湖南大学大学生创新实验一等奖
2008 本科生国家奖学金

研究兴趣：
新型有机合成方法学;不对称催化;活性天然产物及药物分子的合成

近期主要代表论著：

30. Yu, Y.-Z.; Bai, J.; Peng, J.-M.; Yao, J.-S.; Zhuo, C.-X.* Modular access to meta-substituted benzenes via Mo-catalyzed intermolecular deoxygenative benzene formation. J. Am. Chem. Soc. 2023, 145, doi: 10.1021/jacs.3c01330.
29. Shi, X.-N.; Wang, J.-L.; Wu, J.-B.; Zhuo, C.-X.* Synthesis of 2-boryl allylboronates by a bimetallic platinum/zinc-promoted diborylation of propargylic amines. Synlett 2023, 34, doi:10.1055/a-2030-6797. (Invited contribution to the Special Edition Thieme Chemistry Journals Awardees 2022)
28. Cao, L.-Y.; Wang, J.-L.; Wang, K.; Wu, J.-B.; Wang, D.-K.; Peng, J.-M.; Bai, J.; Zhuo, C.-X.* Catalytic asymmetric deoxygenative cyclopropanation reactions by a chiral salen-Mo catalyst. J. Am. Chem. Soc. 2023, 145, 2765–2772. (Selected as JACS Supplementary Cover)
27. Dong, Y.-Q.^#; Wang, K.^#; Zhuo, C.-X.* Molybdenum-catalyzed intermolecular deoxygenative cross coupling reactions of 1,2-diketones with ɑ-ketoamides. ACS Catal. 2022, 12, 11428–11435. (^#Equal contribution) Top 20 most downloaded articles in October 2022.
26. Li, J.-T.; Luo, J.-N.; Wang, J.-L.; Wang, D.-K.; Yu, Y.-Z.; Zhuo, C.-X.* Stereoselective intermolecular radical cascade reactions of tryptophans or ɤ-alkenyl-α-amino acids with acrylamides via photoredox catalysis. Nat. commun. 2022, 13, 1778. DOI: 10.1038/s41467-022-29464-5.
25.Wang, J.-L.; Zhuo, C.-X.*Catalytic deoxygenative cyclopropanation of 1,2-dicarbonyl or monocarbonyl compounds via molybdenum catalysis. Synlett 2022, 33, 599–608. (Invited Synpacts)
24. Cao, L.-Y.; Luo, J.-N.; Yao, J.-S.; Wang, D.-K.; Dong, Y.-Q.; Zheng, C.; Zhuo, C.-X.* Molybdenum-catalyzed deoxygenative cyclopropanation of 1,2-dicarbonyl or mono-carbonyl compounds. Angew. Chem. Int. Ed. 2021, 60, 15254–15259.
Highlighted by Nature Catalysis 2021, 4, 347.
Highlighted by WileyChem, X-MOL, 研之成理, CBG.
23. Zhuo, C.-X.; Fürstner, A.* Catalysis-based total syntheses of pateamine A and DMDA-Pat A. J. Am. Chem. Soc. 2018, 140, 10514–10523.
Highlighted by Synfacts 2018, 14, 1114.
Top 20 most downloaded articles in September, 2018.
22. Zhuo, C.-X.; Fürstner, A.* Concise synthesis of a pateamine A analogue with in vivo anticancer activity based on an iron catalyzed pyrone ring-opening/cross coupling. Angew. Chem. Int. Ed. 2016, 55, 6051-6056.
21. Zhuo, C.-X.; Zhang, X.; You, S.-L.* Enantioselective synthesis of pyrrole fused piperazine and piperazinone derivatives via Ir-catalyzed asymmetric allylic amination. ACS Catal. 2016, 6, 5307−5310.
Highlighted by Synfacts 2016, 12, 1043.
20. Zhuo, C.-X.; Zhou, Y.; Cheng, Q.; Huang, L.; You, S.-L.* Enantioselective construction of spiroindolines with three contiguous stereogenic centers and chiral tryptamine derivative via the reactive spiroindolenine intermediates. Angew. Chem. Int. Ed. 2015, 54, 14146-14149.
Highlighted by Synfacts 2016, 12, 151.
19. Zhuo, C.-X.; Cheng, Q.; Liu, W.-B.; Zhao, Q.; You, S.-L.* Enantioselective synthesis of pyrrole based spiro- and polycyclic derivatives via Ir-catalyzed asymmetric allylic dearomatization and controllable migration reactions. Angew. Chem. Int. Ed. 2015, 54, 8475-8479.
Highlighted by Synfacts 2015, 11, 944.
18. Zhuo, C.-X.; Zhou, Y.; You, S.-L.* Highly regio- and enantioselective synthesis of poly-substituted 2H-pyrroles via Pd-catalyzed intermolecular asymmetric allylic dearomatization of pyrroles. J. Am. Chem. Soc. 2014, 136, 6590-6593.
Highlighted by J. Am. Chem. Soc. Spotlights (J. Am. Chem. Soc. 2014, 136, 6511.)
Highlighted by the highlight module located on the homepage of JACS (May 5, 2014 – May 15, 2014.)
Highlighted by Synfacts 2014, 10, 820. & Organic Chemistry Portal.
17. Zhuo, C.-X.; Zheng, C.; You, S.-L.* Transition-metal catalyzed asymmetric allylic dearomatization reactions. Acc. Chem. Res. 2014, 47, 2558-2573.
16. Zhuo, C.-X.; You, S.-L.* Palladium-catalyzed intermolecular allylic dearomatization reaction of a-substituted-β-naphthol derivatives: scope and mechanistic investigation. Adv. Synth. Catal. 2014, 356, 2020-2028.
15. Zhuo, C.-X.; You, S.-L.* Palladium-catalyzed intermolecular asymmetric allylic dearomatization reaction of naphthol derivatives. Angew. Chem. Int. Ed. 2013, 52, 10056-10059.
Highlighted by Synfacts 2013, 9, 1308. &Chin. J. Org. Chem. 2013, 33, 2440.
14. Zhuo, C.-X.; Wu, Q.-F; Zhao, Q.; Xu, Q.-L.; You, S.-L.* Enantioselective functionalization of indoles and pyrroles via an in-situ formed spiro-intermediate. J. Am. Chem. Soc. 2013, 135, 8169-8172.
Highlighted by Synfacts 2013, 9, 874.
13. Zhuo, C.-X.; Zhang, W.*; You, S.-L.* Catalytic asymmetric dearomatization reactions. Angew. Chem. Int. Ed. 2012, 51, 12662-12686.
12. Zhuo, C.-X.; Liu, W.-B.; Wu, Q.-F.; You, S.-L.* Asymmetric dearomatization of pyrroles via Ir-catalyzed allylic substitution reaction: enantioselective synthesis of spiro-2H-pyrroles. Chem. Sci. 2012, 3, 205-208.
11. Zheng, C.*; Zhuo, C.-X.; You, S.-L.* Mechanistic insights into the Pd-catalyzed intermolecular asymmetric allylic dearomatization of multisubstituted pyrroles: understanding the remarkable regio- and enantioselectivity. J. Am. Chem. Soc. 2014, 136, 16251-16259.
10. Ye, K.-Y.; Cheng, Q.; Zhuo, C.-X.; You, S.-L.* An iridium(I) N-heterocyclic carbene complex catalyzes asymmetric intramolecular allylic amination reactions. Angew. Chem. Int. Ed. 2016, 55, 8113-8116.
9. Wu, Q.-F; Zheng, C.*; Zhuo, C.-X.; You, S.-L.* Highly efficient synthesis and stereoselective migration reactions of chiral five-membered aza-spiroindolenines: scope and mechanistic understanding. Chem. Sci. 2016, 7, 4453-4459.
8. Zhou, Y.; Zhuo, C.-X.; Gu, Q.; You, S.-L.* Intermolecular dearomatization reaction of pyrroles promoted by silica gel. Adv. Synth. Catal. 2015, 357, 912-916 (VIP).
7. Wang, S.-G.; Yin, Q.; Zhuo, C.-X.; You, S.-L.* Asymmetric dearomatization of β-naphthols through an amination reaction catalyzed by a chiral phosphoric acid. Angew. Chem. Int. Ed. 2015, 54, 647-650.
6. Yang, Z.-P.; Zhuo, C.-X.; You, S.-L.* Ruthenium-catalyzed intramolecular allylic dearomatization/migration reaction of indoles and pyrroles. Adv. Synth. Catal. 2014, 356, 1731-1734.
5. Zhao, Q.; Zhuo, C.-X.; You, S.-L.* Enantioselective synthesis of N-allylindoles via palladium-catalyzed allylic amination/oxidation of indolines. RSC Adv. 2014, 4, 10875-10878.
4. Xu, Q.-L.; Zhuo, C.-X.; You, S.-L.* Highly enantioselective synthesis of tetrahydrocarbolines via iridium-catalyzed intramolecular Friedel-Crafts type allylic alkylation reactions. Org. Lett. 2013, 15, 5909-5911.
3. Liu, W.-B.; Zheng, C.; Zhuo, C.-X.; Dai, L.-X.; You, S.-L.* Ir-catalyzed allylic alkylation reaction with N-aryl phosphoramidite ligands: scope and mechanistic studies. J. Am. Chem. Soc. 2012, 134, 4812-4821.
2. Wu, Q.-F.; Liu, W.-B.; Zhuo, C.-X.; Rong, Z.-Q.; Ye, K.-Y.; You, S.-L.* Iridium-catalyzed intramolecular asymmetric allylic dearomatization of phenols. Angew. Chem. Int. Ed. 2011, 50, 4455-4458.
1. Xia, J.-B.; Zhuo, C.-X.; You, S.-L.* Synthesis of Cyclopropane-containing Building Blocks via Ir-Catalyzed Enantioselective Allylic Substitution Reaction. Chin. J. Chem. 2010, 28, 1525-1528.

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